The white patches impose immense psychological burden, and as a result, there is high demand for treatment. It is characterized by melanocyte loss, which results in patchy depigmentation of the skin and hair. Vitiligo is a common skin disease with an estimated prevalence of 0.5–2% worldwide. These results provide evidence supporting that fractional CO 2 laser is a valuable treatment modality for patients with vitiligo, especially for those with refractory vitiligo. For those with refractory vitiligo, the addition of fractional CO 2 laser to routine treatment modalities was superior to conventional treatment alone in terms of > 50% re-pigmentation (risk ratio (RR) 4.90, 95% confidence interval (95% CI), 1.15–20.93 p = 0.03), physician improvement score (mean difference (MD) 0.81, 95% CI 0.33–1.29 p < 0.001), < 25% re-pigmentation (RR 0.64, 95% CI 0.49–0.85 p=0.002) and patient satisfaction (MD 1.61, 95% CI 0.73–2.49 p < 0.001). ![]() Six studies with 85 participants were included. A systematic review was performed by searching major databases for relevant publications to February 2017. Fractional carbon dioxide (CO 2) laser as an add-on to conventional treatment has been reported to be effective, but there is no consensus on its use. ![]() Treatment of vitiligo is challenging and requires a multidisciplinary approach.
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